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Cell functions - Reproduction & genetics - Protein biosynthesis - mRNA Splicing
mRNA Splicing
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| Description |
Among the pre-mRNA binding factors, the small nuclear ribonucleoprotein particles or "snurps" have a special function.
They recognise RNA segments that are not to be translated into the amino acid sequence of the coded protein.
Several snurps form a spliceosome. In it the sequence that is to be removed, the intron, is initially folded to form a loop.
By cutting out such a segment, the snurps bring the RNA regions required for protein synthesis, the exons, together again.
As a result of the excising of introns, pre-mRNA becomes mRNA proper.
Only when all the introns have been removed, can the mRNA be transported out of the nucleus into the cytoplasm.
The proteins that have bound to the RNA, serve as recognition signals for the transport across the nuclear membrane. They separate from the RNA in the cytoplasm and move back into the nucleus.
Duration: 01:22 min
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Sources
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BEREITER-HAHN, JÜRGEN; PETERS, WINFRIED S.: Nucleus of Life - From Gene to Protein. CD-ROM C 7103. MMcD, Düsseldorf; interActive Systems iAS, Marburg, Berlin; IWF, Göttingen, 2003.
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Abbreviations
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Order |
This film is part of the CD-ROM Nucleus of Life - From Genes to Proteins. You can order it at the IWF Knowledge and Media gGmbH.
Also available as clip.
Order no.:
C 13109
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